Question:easy
The immunoglobulin most commonly involved in multiple myeloma is:
The immunoglobulin most commonly involved in multiple myeloma is:
Show Hint
Pick the immunoglobulin class that makes up roughly half of all myeloma cases.
Updated On: Jun 24, 2026
- IgG
- IgM
- IgA
- IgD
Show Solution
The Correct Option is A
Solution and Explanation
Step 1: Recall that multiple myeloma produces one clonal immunoglobulin spike, the M protein, detectable on serum electrophoresis as a sharp band.
Step 2: Rank the immunoglobulin isotypes by how often they form that spike. Memorize the descending order: IgG far ahead, then IgA, with IgM, IgD, and IgE trailing well behind.
Step 3: Putting numbers to it, IgG dominates at about half of all cases, IgA contributes roughly a fifth, and IgD and IgE are the rarities. This ordering directly identifies the most common offender.
Step 4: Since IgG tops the list, it is the immunoglobulin most commonly involved in multiple myeloma.
\[\boxed{\text{IgG}}\]
Step 2: Rank the immunoglobulin isotypes by how often they form that spike. Memorize the descending order: IgG far ahead, then IgA, with IgM, IgD, and IgE trailing well behind.
Step 3: Putting numbers to it, IgG dominates at about half of all cases, IgA contributes roughly a fifth, and IgD and IgE are the rarities. This ordering directly identifies the most common offender.
Step 4: Since IgG tops the list, it is the immunoglobulin most commonly involved in multiple myeloma.
\[\boxed{\text{IgG}}\]
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