To solve the problem of determining the time taken for the radioactivity of a sample to decay to \(\frac{1}{16}\)th of its initial value, we need to apply the concept of half-life. The half-life of a radioactive substance is the time it takes for half of the substance to decay.
\text{Total time} = 4 \times \text{Half-life} = 4 \times 100 \, \mu \text{s}
\text{Total time} = 400 \, \mu \text{s}
Hence, the time taken for the radioactivity to decay to \(\frac{1}{16}\)th of its initial value is 400 \(\mu \text{s}\).
Thus, the correct answer is 400 μs.