Question:medium

The given sentence is missing in the paragraph below. Decide where it best fits among the options 1, 2, 3, or 4 indicated in the paragraph.
Sentence: In each of the affected males, the genetic defect was located to the X chromosome in the region of p11-12.
Paragraph: The first suggested evidence of a human genetic mutation associated with aggressive behaviour came from a study in 1993. ____ (1)____. Genetic and metabolic studies were conducted on a large Dutch family in which several of the males has a syndrome of borderline mental retardation and abnormal behaviour. ____ (2)____. The undesirable behaviour included impulsive aggression, arson and exhibitionism. ____ (3)____. A point mutation was identified in the eighth exon of the monoamine oxidase A (MAOA) structural gene which changes glutamine to a termination codon. ____ (4)____.

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Inserting sentences in a logical order connects ideas and helps maintain the flow of information.
Updated On: Jul 4, 2026
  • Option 1

  • Option 2

  • Option 3

  • Option 4

Show Solution

The Correct Option is C

Solution and Explanation

The given sentence works like a bridge in a chain that zooms from general to specific: first the affected group is described (the Dutch family with abnormal behaviour), then the sentence pins down where the defect sits (X chromosome, region p11-12), and only after that does the paragraph zoom in further to name the exact gene and exon (MAOA, eighth exon, point mutation). For the phrase "each of the affected males" to make sense, it needs the family and their behaviour already on the table, and for the paragraph to keep narrowing sensibly, the chromosome-region detail must come before the gene-level detail, not after. That placement is right before the sentence about the point mutation in the eighth exon of MAOA, which is blank 3. So the sentence belongs at option 3.
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