Question

The first ever biological sequence database which was developed by Dayhoff and Eck's 1965 is

• A. Atlas of Protein sequence and structure
• B. Atlas of DNA sequence and structure
• C. Atlas of RNA sequence and structure
• D. Atlas of Protein and Nucleic acid sequence and structure

Hint:

Margaret Dayhoff is often called the "mother of bioinformatics." Her work was foundational and centered on \textbf{proteins}. The famous PAM (Point Accepted Mutation) scoring matrices, which are still conceptually important today, were derived from the alignments in her Atlas.

Answer 1

The Correct Option is A

Step 1: Core Idea:
The task is to identify the initial comprehensive biological sequence database, a contribution of Margaret Dayhoff and Richard Eck.
Step 2: Elaboration:
Protein sequencing was ahead of DNA sequencing in the early days of molecular biology. Margaret Dayhoff compiled all known protein sequences in 1965 and published them in the "Atlas of Protein Sequence and Structure". This compilation allowed for the study of protein evolution and the development of the first substitution matrices (PAM matrices) for sequence alignment. DNA and RNA sequencing technologies were not advanced enough at the time to allow for large-scale database creation.
Step 3: Conclusion:
The 1965 publication, "Atlas of Protein Sequence and Structure", by Dayhoff and Eck represents the first biological sequence database.