Question:easy
Tadalafil should NOT be given together with which of the following?
Tadalafil should NOT be given together with which of the following?
Show Hint
Two blood-pressure-lowering drugs together can crash the pressure dangerously.
Updated On: Jun 23, 2026
- Vasodilator
- Antibiotics
- Vasoconstrictors
- Valproate
Show Solution
The Correct Option is A
Solution and Explanation
Step 1: Think pharmacodynamics. Tadalafil blocks PDE-5, raising cyclic GMP, which relaxes smooth muscle in blood vessels and improves flow to target organs.
Step 2: Predict additive risk. Pairing it with any drug that also dilates vessels - nitrates being the classic example - stacks two blood-pressure-lowering effects on top of each other.
Step 3: Foresee the outcome. The result is an abrupt, potentially life-threatening fall in blood pressure, which is why a vasodilator co-prescription is forbidden.
Step 4: Eliminate alternatives. A vasoconstrictor would counteract tadalafil rather than amplify it, and antibiotics or valproate have no comparable additive hypotensive mechanism. \[\boxed{\text{Vasodilator}}\]
Step 2: Predict additive risk. Pairing it with any drug that also dilates vessels - nitrates being the classic example - stacks two blood-pressure-lowering effects on top of each other.
Step 3: Foresee the outcome. The result is an abrupt, potentially life-threatening fall in blood pressure, which is why a vasodilator co-prescription is forbidden.
Step 4: Eliminate alternatives. A vasoconstrictor would counteract tadalafil rather than amplify it, and antibiotics or valproate have no comparable additive hypotensive mechanism. \[\boxed{\text{Vasodilator}}\]
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