Study the following and choose the correct statement:
I. Sickle cell anemia is due to replacement of glutamic acid in 6th position by valine
II. Thalassemia is sex linked disorder due to recessive genes
III. Down syndrome is an allosomal disorder
IV. Phenylketonuria is due to mutation of the gene-PAH in chromosome 12
Show Hint
Down syndrome = Trisomy 21 (autosomal disorder). Phenylketonuria is caused by mutation in the PAH gene on chromosome 12.