Question

Select the correct match

• A. Haemophilia - Y linked
• B. Phenylketonuria - Autosomal dominant trait
• C. Sickle cell anaemia - Autosomal recessive trait, chromosome-11
• D. Thalassemia - X linked

Answer 1

The Correct Option is C

To determine the correct answer, we need to understand the genetic basis and chromosome locations of the traits mentioned in the options.

1. Haemophilia: This is a genetic disorder that impairs the body's ability to make blood clots. It is usually inherited in an X-linked recessive pattern, not Y-linked. Therefore, the match "Haemophilia - Y linked" is incorrect.
2. Phenylketonuria (PKU): PKU is a genetic disorder characterized by an inability to break down the amino acid phenylalanine. It is inherited as an autosomal recessive trait, not as an autosomal dominant trait. Therefore, the match "Phenylketonuria - Autosomal dominant trait" is incorrect.
3. Sickle Cell Anaemia: This is a genetic blood disorder resulting from mutations in the HBB gene, which affects hemoglobin structure. It is inherited as an autosomal recessive trait and the gene is located on chromosome 11. Therefore, the match "Sickle cell anaemia - Autosomal recessive trait, chromosome-11" is correct.
4. Thalassemia: It is a blood disorder involving less hemoglobin and fewer red blood cells than normal and is usually inherited as an autosomal recessive trait, not X-linked. Therefore, the match "Thalassemia - X linked" is incorrect.

Thus, after evaluating the genetic basis and chromosomal location for each disorder, the correct answer is Sickle cell anaemia - Autosomal recessive trait, chromosome-11.