Question:medium

In humans, the condition of color blindness is caused by a recessive allele located on the X chromosome. A color-blind woman marries a man with normal vision. What is the probability that their son will be color-blind?

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For sex-linked traits, remember that males express the phenotype of the single X chromosome they inherit. If a mother is homozygous recessive for a sex-linked recessive trait, all her sons will express the trait, as they inherit her recessive X chromosome.
Updated On: Nov 26, 2025
  • \( 0\% \)
  • \( 25\% \)
  • \( 50\% \)
  • \( 100\% \)
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The Correct Option is D

Solution and Explanation

Color blindness, a sex-linked recessive trait, is caused by the recessive allele \( X^c \) on the X chromosome. Normal vision is determined by the dominant allele \( X^C \). Males, possessing one X and one Y chromosome, display a phenotype dictated by their single X chromosome.

- The female is color-blind, indicating a genotype of \( X^c X^c \) (homozygous recessive). - The male has normal vision, with a genotype of \( X^C Y \) (hemizygous for the dominant allele).

To ascertain the probability of their son being color-blind, a Punnett square is employed to analyze potential offspring genotypes.

The female (\( X^c X^c \)) can only contribute an \( X^c \) gamete. The male (\( X^C Y \)) can contribute either an \( X^C \) or a \( Y \) gamete. The resultant offspring genotypes are:

\[ \begin{array}{c|cc} & X^c & X^c
\hline X^C & X^C X^c & X^C X^c
Y & X^c Y & X^c Y
\end{array} \]

- Daughters (\( X^C X^c \)): They inherit \( X^C \) from their father and \( X^c \) from their mother. They are carriers with normal vision, as the dominant \( X^C \) allele masks the recessive \( X^c \). - Sons (\( X^c Y \)): They inherit \( X^c \) from their mother and \( Y \) from their father. Due to the presence of the recessive \( X^c \) allele and the absence of a second X chromosome to counteract it, they are color-blind.

Given that all sons will possess the genotype \( X^c Y \), they will all be color-blind.

Consequently, the probability of their son being color-blind is \( 100\% \).
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