Question

Match the LIST-I with LIST-II. \[ \begin{array}{|l|l|} \hline \textbf{LIST I} & \textbf{LIST II} \\ \hline A. \ \text{Franklin Stahl} & I. \ \beta\text{-form of DNA} \\ B. \ \text{Maurice Wilkins} & II. \ \text{Estimated absolute amount of each Base} \\ C. \ \text{Erwin Chargaff} & III. \ \text{Proposed two polynucleotide chain} \\ D. \ \text{Watson and Crick} & IV. \ \text{Individual strands of Duplexes are entirely heavy or light} \\ \hline \end{array} \]

• A. A - IV, B - II, C - III, D - I
• B. A - IV, B - II, C - I, D - III
• C. A - II, B - III, C - I, D - IV
• D. A - IV, B - I, C - II, D - III

Hint:

Remember:
- Franklin Stahl → Semi-conservative replication.
- Wilkins → Base estimates & X-ray diffraction.
- Chargaff → Base pairing rules.
- Watson & Crick → Double-helix B-DNA structure.

Answer 1

The Correct Option is A

Step 1: Franklin Stahl.
Collaborated with Matthew Meselson on the Meselson–Stahl experiment, proving DNA's semi-conservative replication. They utilized nitrogen isotopes to demonstrate that DNA strands could be entirely heavy or light. Therefore, Franklin Stahl corresponds to IV.

Step 2: Maurice Wilkins.
Co-led X-ray diffraction studies of DNA with Rosalind Franklin. His contributions included estimating the absolute base quantities and advancing crystallographic imaging. Thus, Maurice Wilkins corresponds to II.

Step 3: Erwin Chargaff.
Formulated Chargaff’s rules, stating that in DNA, adenine quantities match thymine, and cytosine quantities match guanine. This established the base-pairing principle and facilitated the deduction of DNA's structure, supporting two polynucleotide chains with complementary bases. Hence, Erwin Chargaff corresponds to III.

Step 4: Watson and Crick.
Proposed the double-helix model of DNA, identifying the B-form as the most stable under physiological conditions. Consequently, Watson and Crick correspond to I.

Final Matching:
A - IV, B - II, C - III, D - I

\[\boxed{\text{Correct option is (1)}}\]