Question

Match List I with List II

List I	Ion Channel Defects	List II: Disease
A	Na+	(i) Polycystic kidney disease
B	Ca2+	(ii) Generalized epilepsy
C	K+	(iv) Dominant deafness
D	Cl-	(iii) Cystic fibrosis

Choose the correct answer from the options given below:

• (A) - (I), (B) - (II), (C) - (III), (D) - (IV)
• (A) - (III), (B) - (IV), (C) - (I), (D) - (II)
• (A) - (II), (B) - (IV), (C) - (III), (D) - (I)
• (A) - (IV), (B) - (I), (C) - (II), (D) - (III)

Hint:

Key associations for ion channel defects:
• Na⁺ = Cystic fibrosis.
• Ca²⁺ = Dominant deafness.
• K⁺ = Polycystic kidney disease.
• Cl = Generalized epilepsy.
Understanding these associations aids in solving similar questions quickly.

Answer 1

The Correct Option is B

- Na⁺ (A - III): Sodium ion channel defects are associated with cystic fibrosis.
- Ca²⁺ (B - IV): Calcium ion channel defects are linked to dominant deafness.
- K⁺ (C - I): Defective potassium ion channels cause polycystic kidney disease.
- Cl (D - II): Chloride ion channel dysfunction is connected to generalized epilepsy.