Step 1: Set up the right angle at the point of contact.
Since PA is tangent to the circle at A, the radius OA is perpendicular to PA, so $\angle OAP=90^\circ$.
Step 2: Use the exterior angle theorem on triangle OAP.
$\angle POB$ is the exterior angle of $\Delta OAP$ at O, so it equals the sum of the two interior opposite angles: $\angle POB=\angle OAP+\angle APO$.
Step 3: Solve for the unknown angle.
$125^\circ = 90^\circ+\angle APO \implies \angle APO = 35^\circ$.
\[ \boxed{35^\circ} \]