Step 1: Note the truth values.
We are told $p$ and $q$ are true and $r$ is false. We test the statement in option 4.
Step 2: Inner biconditional.
Since $p$ and $q$ are both true, $p \leftrightarrow q$ is true (both sides agree).
Step 3: The implication.
Now $(p\leftrightarrow q)\rightarrow r$ becomes $\text{T}\rightarrow \text{F}$. A true statement implying a false one is false.
Step 4: Match the claim.
Option 4 says this has truth value F, which is exactly what we found, so option 4 is the correct choice.
\[ \boxed{(p\leftrightarrow q)\rightarrow r \text{ is } F} \]