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Identify the Iminostilbene analog?

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Several anti-epileptic drugs are named after the core ring system they are built on. The iminostilbene ring is a special three-ring structure.
Updated On: Jun 24, 2026
  • Phenytoin
  • Ethotoin
  • Lamotrigine
  • Carbamazepine
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The Correct Option is D

Solution and Explanation

Step 1: Understand the term Iminostilbene.
Iminostilbene is a tricyclic ring system. It looks like stilbene (two phenyl rings joined by a double bond) but has a nitrogen atom bridging the two phenyl rings, making it an imino (nitrogen-containing) stilbene. The key feature is a dibenzazepine skeleton with a C=C double bond in the central seven-membered ring.

Step 2: Go through each option.
Phenytoin (Option 1) is a hydantoin derivative, not a tricyclic dibenzazepine. Ethotoin (Option 2) is also a hydantoin. Lamotrigine (Option 3) belongs to the phenyltriazine class. These three do NOT have the iminostilbene skeleton.

Step 3: Identify Carbamazepine's structure.
Carbamazepine (Option 4) is chemically named 5H-dibenz[b,f]azepine-5-carboxamide. Its core is two benzene rings fused to a seven-membered azepine ring containing a nitrogen and a C=C double bond. This is exactly the iminostilbene scaffold with a carboxamide substituent.

Step 4: Why Carbamazepine is the correct analog.
The iminostilbene scaffold gives carbamazepine its rigidity and allows it to stabilize the inactivated state of voltage-gated sodium channels, its mechanism for antiepileptic action. The C=C double bond in the azepine ring is the stilbene part, and the ring nitrogen is the imino part.

Step 5: Rule out distractors firmly.
Phenytoin and ethotoin act on the same sodium channel target but through a hydantoin ring, not an iminostilbene. Lamotrigine is a triazine derivative. None of options 1, 2, or 3 share the dibenzazepine-iminostilbene framework.


Answer: Option (4) — Carbamazepine
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