Question

Identify the correct sequence of the given enzymes involved in the TCA cycle:
(A) Aconitase
(B) Fumarase
(C) Malate dehydrogenase
(D) α-ketoglutarate dehydrogenase
Choose the correct answer from the options given below:

• A. (A), (B), (C), (D)
• B. (A), (D), (B), (C)
• C. (B), (A), (D), (C)
• D. (C), (B), (D), (A)

Hint:

Recall the sequence of enzyme actions in the TCA cycle and the transformations they facilitate.

Answer 1

The Correct Option is B

The correct sequence is:
1. Aconitase facilitates the conversion of citrate into isocitrate.
2. The enzyme α-ketoglutarate dehydrogenase mediates the transformation of α-ketoglutarate into succinyl-CoA.
3. Fumarase performs the hydration of fumarate, yielding malate.
4. Malate dehydrogenase then transforms malate into oxaloacetate, thereby concluding the cycle.