Question

Hemodialysis is mandatory in which poisoning?

• A. Copper sulphate poisoning
• B. Ethanol poisoning
• C. Amphetamine poisoning
• D. Organophosphorus poisoning

Hint:

Think about which poison is small and water soluble with low protein binding, since dialysis clears those best.

Answer 1

The Correct Option is B

Step 1: Learn the rule for a dialyzable poison.
A poison can be pulled out by a dialysis machine only if it moves easily out of the blood and across the membrane. Four things decide this: small molecular size, low binding to plasma proteins, a small volume of distribution so it stays mostly in the blood, and good water solubility.

Step 2: Score each option.
Ethanol is a very small, water loving molecule that barely binds plasma proteins and stays mostly in body water, so it scores well on every point. Copper sulphate mainly damages cells directly, and its danger comes from hemolysis and organ injury rather than a blood level that dialysis reverses. Amphetamine and organophosphorus compounds are both fat soluble and bind heavily to tissue, so most of the drug sits outside the blood at any moment and a dialysis filter cannot reach it.

Step 3: Match the scoring to real treatment.
When severe alcohol poisoning causes coma or dangerously slow breathing, or when another toxic alcohol was taken at the same time, and supportive steps like airway protection, fluids, and glucose are not enough, hemodialysis is used to clear the ethanol fast. Copper sulphate, amphetamine, and organophosphorus poisoning are instead managed with chelation, sedation and supportive care, or atropine plus pralidoxime, none of which need a dialysis machine to remove the poison itself.

Step 4: Conclude.
Only ethanol fits the pattern of a poison that dialysis reliably clears.
\[ \boxed{\text{Ethanol poisoning}} \]