Question:medium
Flexner-Wintersteiner rosette is seen in?
Flexner-Wintersteiner rosette is seen in?
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Cells around an empty lumen with cytoplasmic projections - retinal tumor.
Updated On: Jun 24, 2026
- Hepatoblastoma
- Nephroblastoma
- Neuroblastoma
- Retinoblastoma
Show Solution
The Correct Option is D
Solution and Explanation
Step 1: Match the rosette type to its tumor. A Flexner-Wintersteiner rosette signals retinoblastoma.
Step 2: Identify it histologically - tumor cells encircle a true, virtually empty lumen, and thin cytoplasmic extensions reach inward toward that lumen, mimicking primitive photoreceptors. The same rosette can appear in other primitive neuroectodermal lesions like medulloblastoma and pineoblastoma.
Step 3: Contrast with Homer-Wright rosettes, where the centre is filled with fibrillary neuropil and which typify neuroblastoma and medulloblastoma. Wilms tumor and hepatoblastoma do not form this rosette, so they are excluded.
\[\boxed{\text{Retinoblastoma}}\]
Step 2: Identify it histologically - tumor cells encircle a true, virtually empty lumen, and thin cytoplasmic extensions reach inward toward that lumen, mimicking primitive photoreceptors. The same rosette can appear in other primitive neuroectodermal lesions like medulloblastoma and pineoblastoma.
Step 3: Contrast with Homer-Wright rosettes, where the centre is filled with fibrillary neuropil and which typify neuroblastoma and medulloblastoma. Wilms tumor and hepatoblastoma do not form this rosette, so they are excluded.
\[\boxed{\text{Retinoblastoma}}\]
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