Question

During FISH technique, is any fluorescence detected in the der 9 chromosome? Why?

Hint:

In a standard CML patient using dual-color dual-fusion FISH probes, interphase nuclei will display 1 normal red signal (normal 9), 1 normal green signal (normal 22), and 2 yellow fusion signals (one on der 22 Philadelphia, and one on the reciprocal der 9).

Answer 1