Question

Chloroquine contains chlorine at _______

• A. \(2^{nd}\)
• B. \(4^{th}\)
• C. \(7^{th}\)
• D. \(8^{th}\)

Hint:

Chloroquine is a 4-aminoquinoline derivative with chlorine at the \(7^{th}\) position.

Answer 1

The Correct Option is C

Step 1: Understanding the Concept:
Chloroquine is an important antimalarial drug. Understanding its chemical structure is essential for identifying its pharmacophore and medicinal chemistry properties.
Step 2: Detailed Explanation:
1. Nucleus: Chloroquine is a derivative of 4-aminoquinoline.
2. Chemical Name: Its IUPAC name is \(N^{4}\)-(7-chloroquinolin-4-yl)-\(N^{1},N^{1}\)-diethylpentane-1,4-diamine.
3. Substitution: In the quinoline ring system, the nitrogen is at position 1. The side chain is attached at the 4th position, and a chlorine atom is substituted at the 7th position. This chlorine atom is crucial for its antimalarial activity.
Step 3: Final Answer:
The chlorine substituent in the quinoline ring of chloroquine is located at the 7th position.