Question:medium
Calciphylaxis is a severe, life-threatening condition that occurs most commonly in:
Calciphylaxis is a severe, life-threatening condition that occurs most commonly in:
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Calciphylaxis is classically seen in ESRD patients on haemodialysis.
Updated On: Jun 24, 2026
- Parathyroidectomy
- Medullary carcinoma of thyroid
- Hyperthyroidism
- End-stage renal disease
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The Correct Option is D
Solution and Explanation
Step 1: Calciphylaxis describes calcium laid down in the muscular wall of skin arterioles, choking off blood flow and producing dusky, intensely painful skin necrosis and non-healing ulcers.
Step 2: The root problem is grossly disturbed calcium-phosphate balance, which lets calcium precipitate in soft tissues and vessel walls rather than bone.
Step 3: The patients who reliably show this imbalance are those with failed kidneys. In end-stage renal disease, especially during long-term haemodialysis, high phosphate, raised calcium-phosphate product and secondary hyperparathyroidism set the stage for arteriolar calcification.
Step 4: The thyroid options and parathyroidectomy do not create this metabolic milieu, so they are not the usual cause. The condition clusters in dialysis-dependent renal failure.
\[\boxed{\text{End-stage renal disease}}\]
Step 2: The root problem is grossly disturbed calcium-phosphate balance, which lets calcium precipitate in soft tissues and vessel walls rather than bone.
Step 3: The patients who reliably show this imbalance are those with failed kidneys. In end-stage renal disease, especially during long-term haemodialysis, high phosphate, raised calcium-phosphate product and secondary hyperparathyroidism set the stage for arteriolar calcification.
Step 4: The thyroid options and parathyroidectomy do not create this metabolic milieu, so they are not the usual cause. The condition clusters in dialysis-dependent renal failure.
\[\boxed{\text{End-stage renal disease}}\]
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