Question

Assertion (A): Aromatic primary amines cannot be prepared by Gabriel Phthalimide synthesis.
Reason (R): Ary1 halides do not undergo nucleophilic substitution reaction with the anion formed by phthalimide.

• (A) and (R) are true, and (R) is the correct explanation of (A).
• (A) and (R) are true, but (R) is not the correct explanation of (A).
• (A) is true, but (R) is false.
• (A) is false, but (R) is true.

Hint:

When preparing amines, remember that aromatic halides typically require stronger conditions or a different synthetic approach due to their stability.

Answer 1

The Correct Option is A

The Gabriel Phthalimide synthesis proceeds via nucleophilic substitution, where the phthalimide anion acts as the nucleophile to generate primary amines. Aromatic halides exhibit reduced reactivity in nucleophilic substitution due to their resonance stabilization. Consequently, Statement (A) is accurate, and Statement (R) accurately elucidates the challenges in synthesizing aromatic primary amines.