Question:medium
All of the following decrease bone resorption in osteoporosis except?
All of the following decrease bone resorption in osteoporosis except?
Show Hint
One of these builds bone (anabolic PTH) rather than blocking osteoclasts.
Updated On: Jun 24, 2026
- Alendronate
- Etidronate
- Strontium
- Teriparatide
Show Solution
The Correct Option is D
Solution and Explanation
Sort the four drugs into the two fundamental categories of osteoporosis treatment. The antiresorptive camp works by shutting down osteoclasts so that existing bone is not broken down: this includes the bisphosphonates alendronate and etidronate, which bind hydroxyapatite and poison osteoclast function, and strontium, which is conventionally placed with the antiresorptives for its osteoclast-suppressing component. All three therefore decrease bone resorption. The odd drug out is teriparatide, a fragment of parathyroid hormone administered as once-daily injections. Although chronically high PTH dissolves bone, the intermittent low-dose pulse delivered by teriparatide flips the effect and powerfully stimulates osteoblasts, making it an anabolic, bone-forming agent rather than a resorption blocker. Since the stem asks which drug does not reduce resorption, the formation-stimulating PTH analogue is the answer. \[\boxed{\text{Teriparatide}}\]
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