Question

Write the therapeutic use and the animal cell line employed in obtaining any three of the following protein pharmaceuticals:

Hint:

Memorizing a few key protein pharmaceuticals with their application, and also the commonly used cell lines is important.

Answer 1

(A) Erythropoietin: Therapeutic Use: Treatment of anemia, particularly in patients with kidney disease or undergoing chemotherapy. Animal Cell Line: Commonly produced using the CHO (Chinese Hamster Ovary) cell line.

(B) Herceptin: Therapeutic Use: Therapy for breast cancer, especially when cancer cells overexpress HER2 protein. Animal Cell Line: Typically produced utilizing the CHO cell line.

(C) Interleukin-2: Therapeutic Use: Primarily used for cancer treatment. Animal Cell Line: Most frequently produced using CHO cells.

(D) Tissue plasminogen activator (tPA): Therapeutic Use: Treatment of stroke and dissolution of blood clots. Animal Cell Line: Produced using CHO cells.