Question

Why does a patient of ADA-deficiency require repeated infusions of genetically engineered lymphocytes? Suggest a possible permanent remedy.

Hint:

Gene therapy for ADA deficiency is a promising approach for curing immune disorders.

Answer 1

A deficiency in Adenosine Deaminase (ADA) causes significant impairment of the immune system. Temporary immune system restoration can be achieved through repeated infusions of engineered lymphocytes. A definitive solution involves gene therapy: a functional ADA gene is inserted into the patient's bone marrow cells, enabling continuous enzyme production throughout their life.