Griffith's experiment provided the first evidence of genetic transformation, but it was later research by Avery, MacLeod, and McCarty that identified DNA as the transforming principle.
In 1928, Frederick Griffith first demonstrated the transforming principle. His experiment revealed that a non-virulent bacterial strain could become virulent upon exposure to heat-killed virulent bacteria, suggesting a "transforming factor" caused the genetic change. This finding paved the way for Avery and colleagues to later identify DNA as this factor.
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