Question:medium
Which prostaglandin analogue is used to keep the ductus arteriosus patent in patent ductus arteriosus (PDA)?
Which prostaglandin analogue is used to keep the ductus arteriosus patent in patent ductus arteriosus (PDA)?
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A PGE-1 analogue keeps the duct open; misoprostol and alprostadil are the examples.
Updated On: Jun 24, 2026
- Anaprostone
- Misoprostol
- Danaprostone
- PGE-2
Show Solution
The Correct Option is B
Solution and Explanation
Step 1: Whether you want the ductus arteriosus open or closed determines the drug class. To hold the duct open in duct-dependent lesions, a prostaglandin E1 analogue is given because PGE-1 directly dilates ductal tissue.
Step 2: The PGE-1 agents used clinically for this are alprostadil and misoprostol. Of the listed choices, misoprostol fits this role, so it is the answer.
Step 3: By contrast, to shut a patent duct in a premature baby, prostaglandin synthesis inhibitors like indomethacin or ibuprofen are used, which is the reverse pharmacological action.
Step 4: The remaining options, anaprostone, danaprostone and PGE-2, are not the recognised analogues for maintaining patency, confirming misoprostol as correct.
\[\boxed{\text{Misoprostol}}\]
Step 2: The PGE-1 agents used clinically for this are alprostadil and misoprostol. Of the listed choices, misoprostol fits this role, so it is the answer.
Step 3: By contrast, to shut a patent duct in a premature baby, prostaglandin synthesis inhibitors like indomethacin or ibuprofen are used, which is the reverse pharmacological action.
Step 4: The remaining options, anaprostone, danaprostone and PGE-2, are not the recognised analogues for maintaining patency, confirming misoprostol as correct.
\[\boxed{\text{Misoprostol}}\]
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