Question:medium
Which option best explains the LDH flipped (flipping) pattern?
Which option best explains the LDH flipped (flipping) pattern?
Show Hint
After an MI the heart isoenzyme overtakes the normally dominant serum one.
Updated On: Jun 24, 2026
- LDH 1 > LDH 2
- LDH 2 > LDH 1
- LDH 2 > LDH 3
- LDH 3 > LDH 2
Show Solution
The Correct Option is A
Solution and Explanation
Step 1: Start from the normal serum hierarchy of LDH isoenzymes, where $LDH_2 > LDH_1$. Step 2: The heart is rich in LDH-1 (composed of four H subunits), so a healthy serum still keeps LDH-2 on top. Step 3: When the myocardium is injured, as in acute myocardial infarction, it spills LDH-1 into the circulation in such quantity that the order reverses to $LDH_1 > LDH_2$ - this reversal is the flipping effect. Step 4: Since the question asks which inequality represents the flip, the correct description is LDH 1 greater than LDH 2.\[\boxed{\text{LDH 1 > LDH 2}}\]
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