Question:medium
Which one of the following statements concerning gluconeogenesis is correct?
Which one of the following statements concerning gluconeogenesis is correct?
Show Hint
Liver makes glucose to keep levels normal between meals.
Updated On: Jun 24, 2026
- It occurs in muscle
- It is stimulated by fructose 2,6-bisphosphate
- It is inhibited by elevated levels of acetyl CoA
- It is important in maintaining blood glucose during the normal overnight fast
Show Solution
The Correct Option is D
Solution and Explanation
Step 1: Evaluate each statement against the physiology of glucose production. Gluconeogenesis is a hepatic and renal process that defends the blood glucose level during fasting.
Step 2: Muscle cannot carry it out to completion because it has no glucose-6-phosphatase, so the muscle statement fails. Fructose 2,6-bisphosphate is the master activator of glycolysis and a brake on gluconeogenesis, so that statement is also false.
Step 3: Acetyl CoA, which rises in fasting as fat is oxidised, is an allosteric activator of pyruvate carboxylase and therefore stimulates gluconeogenesis; the claim that it inhibits the pathway is incorrect.
Step 4: The remaining choice is sound: in the post-absorptive (overnight fasting) state, gluconeogenesis together with glycogenolysis keeps blood glucose steady, and once glycogen is exhausted gluconeogenesis carries the entire load.
\[\boxed{\text{It maintains blood glucose during the normal overnight fast}}\]
Step 2: Muscle cannot carry it out to completion because it has no glucose-6-phosphatase, so the muscle statement fails. Fructose 2,6-bisphosphate is the master activator of glycolysis and a brake on gluconeogenesis, so that statement is also false.
Step 3: Acetyl CoA, which rises in fasting as fat is oxidised, is an allosteric activator of pyruvate carboxylase and therefore stimulates gluconeogenesis; the claim that it inhibits the pathway is incorrect.
Step 4: The remaining choice is sound: in the post-absorptive (overnight fasting) state, gluconeogenesis together with glycogenolysis keeps blood glucose steady, and once glycogen is exhausted gluconeogenesis carries the entire load.
\[\boxed{\text{It maintains blood glucose during the normal overnight fast}}\]
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