This question checks whether you can separate the routine digitalis ECG effect from a genuine toxicity arrhythmia.
ST segment depression: this is the expected therapeutic 'digitalis effect' at normal doses, not proof of toxicity.
Atrial tachycardia with variable block: toxic digoxin levels raise atrial automaticity while also depressing AV conduction, so a fast atrial focus fires but only some beats reach the ventricles - this dual signature is the classic toxicity arrhythmia.
Atrial flutter: a nonspecific arrhythmia with many causes, not a specific fingerprint of digitalis toxicity.
Shortening of PR interval: digitalis toxicity slows AV nodal conduction and prolongs the PR interval, so a shortened PR points elsewhere entirely (such as pre-excitation).
Correct answer: Atrial tachycardia with variable block.