Question:medium

Which one of the following correctly describes the role of signal recognition particles?

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Think of the SRP as a postal worker for the cell. It reads the 'zip code' (the signal peptide) on a newly made protein and ensures it gets delivered to the correct 'address' (the endoplasmic reticulum).
Updated On: Feb 18, 2026
  • Aid in the decoding of the information carried by the signal peptide for the secretory protein.
  • Aid in recognizing the antigen for inflammatory response.
  • Aid in receiving coated vesicles for exocytosis.
  • Aid in deciphering the genetic code for protein synthesis.
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The Correct Option is A

Solution and Explanation

Step 1: Understanding the Concept:
The Signal Recognition Particle (SRP) is a key ribonucleoprotein complex involved in protein targeting. It identifies and directs proteins destined for the secretory pathway (secretion, membrane insertion, or targeting to organelles) to the endoplasmic reticulum (ER).

Step 2: Detailed Explanation:
This process, called co-translational targeting, proceeds as follows:
1. A ribosome starts translating an mRNA. If the protein enters the secretory pathway, an N-terminal signal peptide emerges.
2. The SRP recognizes and binds this signal peptide, pausing translation.
3. The entire complex (SRP, ribosome, polypeptide) is then directed to the ER membrane, where the SRP binds an SRP receptor.
4. The ribosome docks at the translocon (an ER membrane protein channel), translation restarts, and the polypeptide threads through the channel into the ER lumen.
Essentially, the SRP 'decodes' the signal peptide, acting as an address label for the ER.

Step 3: Analyzing the Options:
- (A) Aid in the decoding of the information carried by the signal peptide for the secretory protein: This accurately describes the SRP's main function: recognizing the signal peptide and initiating targeting.
- (B) Aid in recognizing the antigen for inflammatory response: This is the function of immune components like antibodies and T-cell receptors.
- (C) Aid in receiving coated vesicles for exocytosis: This involves proteins like SNAREs, which fuse vesicles with the plasma membrane.
- (D) Aid in deciphering the genetic code for protein synthesis: This is the role of the ribosome and tRNAs.

Step 4: Final Answer:
Option (A) is the most accurate and specific description of the Signal Recognition Particle's function.
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