Question

Which of the following synthetic antimuscarinic drugs is correctly matched with its primary clinical use?

• A. Pirenzepine – Antiparkinsonian agent
• B. Cyclopentolate – Mydriatic
• C. Glycopyrrolate – Antispasmodic
• D. Oxybutynin – Anti-ulcer agent

Hint:

Antimuscarinic drugs block muscarinic acetylcholine receptors, but different members are used for very different clinical purposes depending on where they act best in the body.

Answer 1

The Correct Option is B

Step 1: What the question is asking.
We need to find which synthetic antimuscarinic drug is correctly paired with its clinical use.

Step 2: Evaluate Option 1 - Pirenzepine.
Pirenzepine is a selective M₁ muscarinic blocker. It is used as an anti-ulcer agent (reduces gastric acid secretion), not as an antiparkinsonian agent. So Option 1 is wrong.

Step 3: Evaluate Option 2 - Cyclopentolate.
Cyclopentolate is a synthetic antimuscarinic drug used as a mydriatic (dilates the pupil) and cycloplegic (paralyzes the ciliary muscle). It is very commonly used in ophthalmology for eye examinations. This is the correct match.

Step 4: Evaluate Option 3 - Glycopyrrolate.
Glycopyrrolate is a quaternary ammonium antimuscarinic. Its main uses include reducing secretions before surgery and treating peptic ulcers. It is not primarily an antispasmodic.

Step 5: Evaluate Option 4 - Oxybutynin.
Oxybutynin has both antimuscarinic and direct smooth muscle relaxant properties. It is used for overactive bladder (urinary incontinence), not as an anti-ulcer agent.

Step 6: Conclusion.
Only Cyclopentolate is correctly matched as a Mydriatic.
Answer: Option (2) — Cyclopentolate – Mydriatic