Question

Which of the following statements are not correct about first order kinetics?
(A). Clearance remains constant
(B). Fixed amount of the drug is eliminated
(C). Half-life increases with dose
(D). Decrease in clearance with increasing dose
Choose the correct answer from the options given below:

• A. (A), (B) and (D) only.
• B. (C) and (D) only.
• C. (B), (C) and (D) only.
• D. (A) and (D) only.

Hint:

First-order kinetics: Constant fraction eliminated, Clearance and Half-life are constant.
Zero-order kinetics: Constant amount eliminated, Clearance decreases and Half-life increases with dose.

Answer 1

The Correct Option is C