Question:medium
Which of the following statements about high-density lipoproteins (HDL) is FALSE?
Which of the following statements about high-density lipoproteins (HDL) is FALSE?
Show Hint
HDL is protective; pick the statement that contradicts its antioxidant role.
Updated On: Jun 24, 2026
- HDL increases oxidation of LDL
- HDL reduces foam cell production by LDL
- HDL is the best predictor of coronary artery disease
- HDL helps to clear lipids from atheroma
Show Solution
The Correct Option is A
Solution and Explanation
This is a negative-stem question, so the task is to find the one claim about HDL that is incorrect. HDL is the protective, antiatherogenic lipoprotein, and three of the statements correctly describe that protective behavior: it lowers foam cell formation by curbing macrophage uptake of modified LDL, a low HDL value is among the most reliable lipid markers for coronary artery disease, and through reverse cholesterol transport it pulls cholesterol out of atheromatous plaques and ships it to the liver. The remaining statement claims that HDL increases the oxidation of LDL, which is the reverse of reality, because HDL carries antioxidant enzymes such as paraoxonase that actively block LDL oxidation. Since that statement contradicts the true antioxidant function of HDL, it is the false one and therefore the intended answer. \[\boxed{\text{HDL increases oxidation of LDL}}\]
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