Question

Which of the following statements about antibodies is NOT correct?

• A. Human gamma globulins consist of at least 25 to 30 different proteins
• B. A typical immunoglobulin consists of 4 subunits
• C. Gamma globulins are formed predominantly by the liver
• D. Immunoglobulins have a molecular weight of about 1,50,000

Hint:

Think about which cells make antibodies, not which organ makes most other blood proteins.

Answer 1

The Correct Option is C

We need the one wrong statement out of four claims about antibodies.

1. 25 to 30 different proteins: Human gamma globulins really do form a large group of this size once you count all classes and subclasses. True.
2. 4 subunits: A typical antibody like IgG is made of 2 heavy chains and 2 light chains, so 4 chains total. True.
3. Formed predominantly by the liver: Antibodies are made by plasma cells, which develop from B lymphocytes in lymph nodes, spleen, and bone marrow. The liver makes albumin and most clotting factors, but not gamma globulins. This claim is false.
4. Molecular weight about 1,50,000: This matches IgG closely. True.

Since three statements hold up and only the liver claim fails, that is the incorrect one.

Let's summarize:

• Antibodies come from plasma cells, not the liver.
• The liver makes other plasma proteins like albumin, but immunoglobulins are a B cell product.

So the statement that is NOT correct is that gamma globulins are formed predominantly by the liver.