Question

Which of the following statement(s) is/are true about the role of Malonyl CoA in fatty acid metabolism?
(A). It is an inhibitor of the enzyme “Carnitine acyltransferase”
(B). High levels of malonyl CoA suppress fatty acid entry into the mitochondria
(C). High levels of malonyl CoA lead to reduced flux of fatty acids towards triglycerides' biosynthesis
(D). Low levels of malonyl CoA favour fatty acid oxidation

Choose the correct answer from the options given below:

• A. (A), (B) and (D) only.
• B. (A), (B) and (C) only.
• C. (A), (B), (C) and (D).
• D. (B), (C) and (D) only.

Hint:

Malonyl-CoA acts as a metabolic gatekeeper.
When the cell has plenty of energy, malonyl-CoA levels rise to build fatty acids and inhibit CPT-1, ensuring that the newly synthesized fatty acids are not simultaneously degraded.

Answer 1

The Correct Option is A