Question

Which of the following statement(s) is/are true about the Type IV isozyme of the hexokinase?
(A). It is highly specific for glucose and is thus often called as glucokinase.
(B). It has much higher \( K_m \) value for glucose
(C). It is allosterically inhibited by glucose-6-phosphate
(D). It is a non-inducible enzyme and follows Michaelis-Menten Kinetics

Choose the correct answer from the options given below:

• A. (A), (B) and (D) only.
• B. (A) and (B) only.
• C. (A), (C) and (D) only.
• D. (A) and (D) only.

Hint:

Remember that glucokinase (Hexokinase IV) acts as a systemic glucose sensor.
Its high \( K_m \) (low affinity) and lack of feedback inhibition by glucose-6-phosphate allow it to function effectively in clearing glucose from the blood after a meal.

Answer 1

The Correct Option is B