Question

Which of the following medications is most commonly linked to the occurrence of fibrous gingival enlargement?

• A. Nifedipine
• B. Acetaminophen
• C. Amoxicillin
• D. Tranexamic acid

Hint:

Remember the “3 P’s” of drug-induced gingival enlargement: Phenytoin, Procardia (nifedipine), and Prograf (cyclosporine).

Answer 1

The Correct Option is A

To determine which medication is most commonly linked to fibrous gingival enlargement, let's evaluate the given options:

1. Nifedipine: Nifedipine is a calcium channel blocker commonly prescribed to treat high blood pressure and angina. One of the known side effects of calcium channel blockers, particularly nifedipine, is gingival overgrowth or enlargement. This condition occurs because these medications can lead to an accumulation of extracellular matrix in the gingival tissues.
2. Acetaminophen: This is an analgesic and antipyretic medication commonly used to treat pain and fever. It does not have an association with gingival enlargement.
3. Amoxicillin: It is a penicillin-type antibiotic used to treat a variety of bacterial infections. There is no evidence linking amoxicillin to gingival enlargement.
4. Tranexamic acid: This medication is an antifibrinolytic agent used to reduce bleeding. It does not cause gingival overgrowth.

Based on the above information, the correct answer is Nifedipine, as it is most commonly linked to fibrous gingival enlargement.