Question:medium
Which of the following is true about gastric carcinoma?
Which of the following is true about gastric carcinoma?
Show Hint
Gastric cancer is an adenocarcinoma, often radioresistant, bleeds occultly, and arises on a low-acid stomach.
Updated On: Jun 24, 2026
- Occult bleeding in stool is not seen
- It is associated with achlorhydria or hypochlorhydria
- It is always squamous cell carcinoma
- It is radiosensitive
Show Solution
The Correct Option is B
Solution and Explanation
Work through each claim against what is known about stomach cancer. First, type: gastric cancer is essentially synonymous with adenocarcinoma because it grows from the mucus-secreting glandular lining; squamous histology is not the rule, so the absolute statement that it is always squamous is wrong.
Second, acid: a low-acid stomach is a danger zone. Long-standing atrophic gastritis, autoimmune destruction of parietal cells (as in pernicious anemia), and Helicobacter pylori driven atrophy all reduce hydrochloric acid, and this hypochlorhydric or achlorhydric mucosa is a classic background for malignant change. This makes the achlorhydria association the correct true statement.
Third, bleeding: an ulcerating tumour sheds blood slowly into the lumen, so faecal occult blood testing is often positive rather than negative, contradicting the first option. Fourth, treatment: the tumour responds poorly to radiotherapy and is managed primarily by resection, so calling it radiosensitive is incorrect.
Only the acid-related statement survives scrutiny.\[\boxed{\text{Associated with achlorhydria or hypochlorhydria}}\]
Second, acid: a low-acid stomach is a danger zone. Long-standing atrophic gastritis, autoimmune destruction of parietal cells (as in pernicious anemia), and Helicobacter pylori driven atrophy all reduce hydrochloric acid, and this hypochlorhydric or achlorhydric mucosa is a classic background for malignant change. This makes the achlorhydria association the correct true statement.
Third, bleeding: an ulcerating tumour sheds blood slowly into the lumen, so faecal occult blood testing is often positive rather than negative, contradicting the first option. Fourth, treatment: the tumour responds poorly to radiotherapy and is managed primarily by resection, so calling it radiosensitive is incorrect.
Only the acid-related statement survives scrutiny.\[\boxed{\text{Associated with achlorhydria or hypochlorhydria}}\]
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