Question:medium
Which of the following is the topical use of Mitomycin C (the medicine shown in the image)?
Which of the following is the topical use of Mitomycin C (the medicine shown in the image)?
Show Hint
Mitomycin C inhibits fibroblast proliferation and is used topically to prevent scar-related stenosis in airway surgeries.
Updated On: Jun 23, 2026
- Subglottic stenosis
- Inlay type I myringoplasty
- Post-adenoidectomy to control bleeding
- Rhino cerebral mucormycosis
Show Solution
The Correct Option is A
Solution and Explanation
Drug identification: The image shows Mitomycin C vials (10 mg and 40 mg). Mitomycin C is an alkylating antibiotic that cross-links DNA and inhibits fibroblast proliferation and collagen deposition.
Topical Mitomycin C in ENT -- key uses:
- Subglottic stenosis: applied topically after endoscopic dilation to prevent re-stenosis by inhibiting fibroblast activity
- Tracheal stenosis post-tracheostomy
- Laryngeal stenosis
- FESS: applied to sinus ostia to prevent post-operative stenosis
- Septoplasty: to prevent synechiae
- Intubation granuloma
Why not the other options?
- Type I myringoplasty uses fascia or perichondrium grafts; no role for Mitomycin C
- Post-adenoidectomy bleeding: managed by electrocautery, packing, or re-ligation
- Rhino-cerebral mucormycosis: treated with IV amphotericin B and radical surgical debridement; Mitomycin C has no role
Memory tip: Mitomycin C = anti-fibrosis drug used wherever stenosis (scarring and narrowing) is the problem in ENT airway surgeries. \[\boxed{\text{Subglottic stenosis}}\]
Topical Mitomycin C in ENT -- key uses:
- Subglottic stenosis: applied topically after endoscopic dilation to prevent re-stenosis by inhibiting fibroblast activity
- Tracheal stenosis post-tracheostomy
- Laryngeal stenosis
- FESS: applied to sinus ostia to prevent post-operative stenosis
- Septoplasty: to prevent synechiae
- Intubation granuloma
Why not the other options?
- Type I myringoplasty uses fascia or perichondrium grafts; no role for Mitomycin C
- Post-adenoidectomy bleeding: managed by electrocautery, packing, or re-ligation
- Rhino-cerebral mucormycosis: treated with IV amphotericin B and radical surgical debridement; Mitomycin C has no role
Memory tip: Mitomycin C = anti-fibrosis drug used wherever stenosis (scarring and narrowing) is the problem in ENT airway surgeries. \[\boxed{\text{Subglottic stenosis}}\]
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