Understanding the Concept:
Compendial monographs specify storage conditions for drug formulations to maintain structural integrity, potency, and safety throughout their shelf life.
Storage Condition Evaluation:
• Cyanocobalamin (Vitamin B12): A water-soluble vitamin that is stable at room temperature but highly sensitive to light (photodegradation) and extreme freezing conditions.
• According to the official United States Pharmacopeia (USP) monograph guidelines, Cyanocobalamin Injection must be preserved in light-resistant, single-dose or multiple-dose containers.
• The specified temperature profile is designated as Controlled Room Temperature, which corresponds to a temperature range of $20^{\circ}\text{C}$ to $25^{\circ}\text{C}$ ($68^{\circ}\text{F}$ to $77^{\circ}\text{F}$). Freezing or excessive cold storage can lead to instability or precipitation issues in the aqueous solution.
Therefore, option (D) is the recommended storage condition.