Question

Which of the following is the primary site of production of Gastrin?

• A. Pylorus
• B. Antrum
• C. Pancreas
• D. Small intestine

Hint:

Think of the G cells located in the lower stomach lining.

Answer 1

The Correct Option is B

This question asks which gut region mainly produces the hormone gastrin.

1. Pylorus: This is the muscular outlet valve of the stomach, not the main site of gastrin producing cells.
2. Antrum: The G cells of the gastric antrum are the main producers of gastrin, releasing it in response to distension and vagal stimulation to drive acid secretion.
3. Pancreas: This organ makes insulin and glucagon, not gastrin, as its primary hormones.
4. Small intestine: This region makes other gut hormones like secretin and cholecystokinin, with only minor gastrin contribution compared to the antrum.

The antrum, home to the G cells, is the correct site of primary gastrin production.

Let's summarize:

• Gastrin is made by G cells concentrated in the gastric antrum.
• This gastrin then stimulates acid secretion from parietal cells elsewhere in the stomach.

So the primary site of gastrin production is the antrum.