Question:easy
Which of the following is the drug of choice for smoking cessation?
Which of the following is the drug of choice for smoking cessation?
Show Hint
Pick the alpha-4 beta-2 nicotinic receptor partial agonist.
Updated On: Jun 23, 2026
- Acamprosate
- Varenicline
- Thalidomide
- Tryptophan
Show Solution
The Correct Option is B
Solution and Explanation
Step 1: Scan the list for any approved anti-smoking agent; the other three belong to completely different indications.
Step 2: Varenicline is the synthetic partial agonist at the alpha-4 beta-2 nicotinic receptor. Acting as a weak agonist it eases withdrawal through modest dopamine release, and acting as an antagonist it occupies the receptor so inhaled nicotine can no longer reward the smoker.
Step 3: Acamprosate curbs alcohol craving, thalidomide treats erythema nodosum leprosum and multiple myeloma, and tryptophan is simply a dietary amino acid - none has a smoking-cessation role.
Step 4: Only one option is a recognized first-line cessation drug.
\[\boxed{\text{Varenicline}}\]
Step 2: Varenicline is the synthetic partial agonist at the alpha-4 beta-2 nicotinic receptor. Acting as a weak agonist it eases withdrawal through modest dopamine release, and acting as an antagonist it occupies the receptor so inhaled nicotine can no longer reward the smoker.
Step 3: Acamprosate curbs alcohol craving, thalidomide treats erythema nodosum leprosum and multiple myeloma, and tryptophan is simply a dietary amino acid - none has a smoking-cessation role.
Step 4: Only one option is a recognized first-line cessation drug.
\[\boxed{\text{Varenicline}}\]
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