Question:easy
Which of the following is NOT an autoimmune disease?
Which of the following is NOT an autoimmune disease?
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Three are antibody-mediated self-attacks; one is a single-gene haemoglobin defect.
Updated On: Jun 24, 2026
- Systemic lupus erythematosus (SLE)
- Grave's disease
- Myasthenia gravis
- Sickle cell disease
Show Solution
The Correct Option is D
Solution and Explanation
Begin by grouping the options by mechanism. SLE, Grave's disease and myasthenia gravis all share one feature: the body attacks itself. In SLE the attack is broad and systemic through immune complexes deposited in skin, joints and kidneys. In Grave's disease a specific autoantibody mimics TSH and overdrives the thyroid. In myasthenia gravis antibodies block and destroy acetylcholine receptors, producing fatigable muscle weakness. Each of these three is therefore immunological in origin.
Sickle cell disease belongs to a completely different category. It is inherited, not acquired through immune dysregulation. A single nucleotide substitution converts glutamate to valine at position six of the beta chain, producing HbS that polymerises when deoxygenated and deforms red cells into sickles. There is no role for autoantibodies or self-directed lymphocytes. Hence among the listed conditions only sickle cell disease falls outside the autoimmune group.
\[\boxed{\text{Sickle cell disease}}\]
Sickle cell disease belongs to a completely different category. It is inherited, not acquired through immune dysregulation. A single nucleotide substitution converts glutamate to valine at position six of the beta chain, producing HbS that polymerises when deoxygenated and deforms red cells into sickles. There is no role for autoantibodies or self-directed lymphocytes. Hence among the listed conditions only sickle cell disease falls outside the autoimmune group.
\[\boxed{\text{Sickle cell disease}}\]
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