Question:medium
Which of the following is NOT a disorder of protein misfolding?
Which of the following is NOT a disorder of protein misfolding?
Show Hint
Three are conformational diseases; one is a bacterial infection.
Updated On: Jun 24, 2026
- Alzheimer's disease
- Tuberculosis
- Cystic fibrosis
- Creutzfeldt-Jakob disease (CJD)
Show Solution
The Correct Option is B
Solution and Explanation
The question asks you to find the one entry that does not belong to the family of conformational, or protein-misfolding, diseases, so screen each item for an abnormally folded protein at the heart of its pathogenesis. Alzheimer's disease qualifies because amyloid-beta plaques and tau tangles are aggregates of mis-shapen protein. Creutzfeldt-Jakob disease qualifies because the prion protein itself converts from its normal alpha-helical form to a pathological beta-sheet-rich form that self-propagates. Cystic fibrosis qualifies because the common delta-F508 mutation yields a CFTR channel that cannot fold correctly and is targeted for premature degradation. That leaves tuberculosis, whose cause is wholly different: it is a chronic granulomatous infection by Mycobacterium tuberculosis, with no misfolded host protein driving the disease. By elimination the exception is the infectious entry.
$ \text{misfolding} = \{\text{Alzheimer, CJD, cystic fibrosis}\},\ \text{infection} = \text{TB} $
\[\boxed{\text{Tuberculosis}}\]
$ \text{misfolding} = \{\text{Alzheimer, CJD, cystic fibrosis}\},\ \text{infection} = \text{TB} $
\[\boxed{\text{Tuberculosis}}\]
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