Question:medium
Which of the following is associated with peripheral artery disease, coronary heart disease and stroke?
Which of the following is associated with peripheral artery disease, coronary heart disease and stroke?
Show Hint
All three are atherosclerotic diseases, and diabetes is the strong shared risk.
Updated On: Jun 24, 2026
- Insulin deficiency
- Hyperestrogenemia
- Hypothyroidism
- Hyperprogesteronemia
Show Solution
The Correct Option is A
Solution and Explanation
Notice that all three named conditions, blocked leg arteries, blocked heart arteries, and brain infarction, share one root mechanism: atherosclerosis affecting the whole arterial tree. So the question is really asking which option accelerates atherosclerosis everywhere.
Insulin deficiency is diabetes mellitus. Diabetes damages vessel walls through chronic high sugar, abnormal lipids, increased clotting tendency, and endothelial dysfunction, and it does so in the coronary, cerebral, and peripheral circulations alike. That makes it the single best link to the listed triad, so it is the answer.
The other choices do not work. High estrogen tends to protect young women's vessels rather than damage them. Low thyroid function can nudge cholesterol upward but is not the textbook cause of this combined picture. Excess progesterone has no established role in producing this set of vascular diseases.
The unifying culprit behind peripheral, coronary, and cerebral artery disease is diabetes driven by insulin deficiency.
\[\boxed{\text{Insulin deficiency}}\]
Insulin deficiency is diabetes mellitus. Diabetes damages vessel walls through chronic high sugar, abnormal lipids, increased clotting tendency, and endothelial dysfunction, and it does so in the coronary, cerebral, and peripheral circulations alike. That makes it the single best link to the listed triad, so it is the answer.
The other choices do not work. High estrogen tends to protect young women's vessels rather than damage them. Low thyroid function can nudge cholesterol upward but is not the textbook cause of this combined picture. Excess progesterone has no established role in producing this set of vascular diseases.
The unifying culprit behind peripheral, coronary, and cerebral artery disease is diabetes driven by insulin deficiency.
\[\boxed{\text{Insulin deficiency}}\]
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