Question:medium
Which of the following is/are true about colchicine?
Which of the following is/are true about colchicine?
Show Hint
Colchicine is a tubulin binder with all the listed effects.
Updated On: Jun 23, 2026
- Acts by neutrophil recruitment
- Causes metaphase arrest
- Useful in urate-lowering therapy
- All of the above
Show Solution
The Correct Option is D
Solution and Explanation
Step 1: Colchicine works through one central action, binding tubulin and blocking microtubule assembly, and several clinical effects flow from this.
Step 2: Without functioning microtubules, neutrophils lose normal motility, so their movement and recruitment into the inflamed gouty joint are disrupted and the release of chemotactic mediators falls. This covers the neutrophil statement.
Step 3: The same anti-microtubule action breaks the mitotic spindle, freezing dividing cells in metaphase, which explains the metaphase arrest statement.
Step 4: Clinically, low daily doses are used alongside urate-lowering therapy to prevent flares when serum urate shifts suddenly. As every option is valid, the correct choice is all of the above.
\[\boxed{\text{All of the above}}\]
Step 2: Without functioning microtubules, neutrophils lose normal motility, so their movement and recruitment into the inflamed gouty joint are disrupted and the release of chemotactic mediators falls. This covers the neutrophil statement.
Step 3: The same anti-microtubule action breaks the mitotic spindle, freezing dividing cells in metaphase, which explains the metaphase arrest statement.
Step 4: Clinically, low daily doses are used alongside urate-lowering therapy to prevent flares when serum urate shifts suddenly. As every option is valid, the correct choice is all of the above.
\[\boxed{\text{All of the above}}\]
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