Question:medium

Which of the following is an example of physical incompatibility:

Updated On: Jul 14, 2026
  • Alkaloidal incompatibility
  • Liquefaction
  • Drug interaction
  • Error in dosage form
Show Solution

The Correct Option is B

Solution and Explanation

Step 1: Understanding the Concept:
Pharmaceutical incompatibilities are grouped into physical, chemical and therapeutic types, and the question wants the option that fits the physical category specifically.

Step 2: Key Concept or Approach:
A physical incompatibility changes the appearance or state of a formulation without forming a new chemical substance, unlike a chemical incompatibility, which does form a new compound.

Step 3: Detailed Explanation:
Alkaloidal incompatibility involves a chemical reaction, such as an alkaloid salt combining with tannins to precipitate out, so it counts as a chemical incompatibility.
Drug interaction describes altered therapeutic effects when two drugs are given together, which falls under therapeutic incompatibility.
Error in dosage form is a manufacturing or formulation mistake, not an ingredient interaction at all.
Liquefaction happens when solids like camphor and menthol are ground together and the mixture turns into a liquid through a eutectic effect, purely a physical state change with no new chemical bond forming, which is exactly what a physical incompatibility means.

Step 4: Final Answer:
Liquefaction is the example of a physical incompatibility among the given options.
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