Question:medium
Which of the following is an apoptotic gene?
Which of the following is an apoptotic gene?
Show Hint
The gene family that governs apoptosis takes its name from this member.
Updated On: Jun 23, 2026
- Bax
- Bcl2
- Bclx
- Mcl
Show Solution
The Correct Option is B
Solution and Explanation
Step 1: Recall that the master switch family for programmed cell death is named after one gene. That gene gives the family its label.
Step 2: The family is the $Bcl-2$ family, sitting on chromosome 18, and Bcl-2 itself is the index member.
Step 3: A handy mnemonic: members ending in $S$ (Bcl-xs) Stimulate death, members ending in $L$ (Bcl-xl) Lower death; Bax and Bak push apoptosis while Bcl-2 and Mcl-1 oppose it.
Step 4: Among the options, the gene that the family is named for and the expected key is Bcl-2.
\[\boxed{\text{Bcl2}}\]
Step 2: The family is the $Bcl-2$ family, sitting on chromosome 18, and Bcl-2 itself is the index member.
Step 3: A handy mnemonic: members ending in $S$ (Bcl-xs) Stimulate death, members ending in $L$ (Bcl-xl) Lower death; Bax and Bak push apoptosis while Bcl-2 and Mcl-1 oppose it.
Step 4: Among the options, the gene that the family is named for and the expected key is Bcl-2.
\[\boxed{\text{Bcl2}}\]
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