Question:easy
Which of the following is a recognised risk factor for Alzheimer's disease?
Which of the following is a recognised risk factor for Alzheimer's disease?
Show Hint
APP gene is on chromosome 21, so trisomy 21 raises amyloid and Alzheimer's risk.
Updated On: Jun 23, 2026
- Klinefelter syndrome
- Low BP
- Down's syndrome
- None
Show Solution
The Correct Option is C
Solution and Explanation
Step 1: Tie Alzheimer's to amyloid and amyloid to its parent protein, APP, which is coded on chromosome 21.
Step 2: Now find the option that adds chromosome 21 material. Down syndrome is trisomy 21, so these patients inherit a third APP gene and overproduce amyloid throughout life.
Step 3: The predictable result is early build-up of amyloid plaques and a very high lifetime risk of Alzheimer-type dementia, often appearing decades earlier than in the general population.
Step 4: Klinefelter (47,XXY) and low blood pressure have no such amyloid link, so the only valid risk factor here is Down syndrome.
\[\boxed{\text{Down's syndrome}}\]
Step 2: Now find the option that adds chromosome 21 material. Down syndrome is trisomy 21, so these patients inherit a third APP gene and overproduce amyloid throughout life.
Step 3: The predictable result is early build-up of amyloid plaques and a very high lifetime risk of Alzheimer-type dementia, often appearing decades earlier than in the general population.
Step 4: Klinefelter (47,XXY) and low blood pressure have no such amyloid link, so the only valid risk factor here is Down syndrome.
\[\boxed{\text{Down's syndrome}}\]
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