Question:medium

Which of the following is a classic example of a MEDIUM-vessel vasculitis?

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PAN and Kawasaki = medium vessel; GPA/MPA = small-vessel ANCA-associated.
Updated On: Jun 25, 2026
  • Leukocytoclastic (cutaneous small-vessel) vasculitis
  • Polyarteritis nodosa (PAN)
  • Granulomatosis with polyangiitis (GPA)
  • Microscopic polyangiitis (MPA)
Show Solution

The Correct Option is B

Solution and Explanation

The Chapel Hill Consensus sorts vasculitis by the dominant calibre of vessel involved. Reading the options against that scheme:

$\text{Leukocytoclastic} \rightarrow$ small (postcapillary venules)
$\text{GPA} \rightarrow$ small (ANCA-associated)
$\text{MPA} \rightarrow$ small (ANCA-associated)
$\text{PAN} \rightarrow$ medium muscular arteries

Polyarteritis nodosa is the textbook necrotising arteritis of medium-sized muscular arteries, characteristically ANCA-negative and linked to hepatitis B, sparing the lungs. The other three sit in the small-vessel compartment.
\[\boxed{\text{PAN is the medium-vessel vasculitis}}\]
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