Question

Which of the following hormone is not secreted by human placenta ?

• A. LH
• B. hCG
• C. Estrogen
• D. Progesterone

Hint:

• Pregnancy-Specific Hormones: Hormones such as hCG, hPL, and relaxin (which is also secreted by the ovary/placenta later in pregnancy) are produced in women exclusively during gestation.

• Clinical Application: Because hCG is produced shortly after the blastocyst implants into the uterine wall, its presence in maternal urine serves as the physiological basis for home pregnancy testing.

Answer 1

The Correct Option is A

Step 1: Understand the ask.
We must find which listed hormone is NOT made by the human placenta.
Step 2: Recall placental hormones.
During pregnancy the placenta acts as a temporary endocrine gland and secretes hCG, human placental lactogen, estrogen, and progesterone.
Step 3: Check hCG.
hCG is produced by the developing chorion/placenta soon after implantation and keeps the corpus luteum active. So hCG IS placental.
Step 4: Check estrogen and progesterone.
Both rise sharply in pregnancy and are made by the placenta to maintain the uterus and support the fetus. So both ARE placental.
Step 5: Check LH.
Luteinizing hormone is a gonadotropin from the anterior pituitary, not the placenta. In fact the high placental estrogen and progesterone suppress pituitary LH and FSH through negative feedback.
Step 6: Conclude.
The odd one out is LH, which is option (1).
\[ \boxed{\text{LH}} \]